You may find it hard to believe that anger may be at the root of your sad and lethargic feelings when you get depressed. But the link between anger and depression has been established centuries ago by the Greek philosophers and then more scientifically by the turn of the 19th century. Treatment with SSRI's is the most widely practiced medication route. But recent research shows that there are two types of depression and that SSRI's are at best no better than a placebo (sugar pill) and that where they are effective, they are more helpful (with psychotherapy) for one more than the other.